...the researchers tested levels of IGF-1 and IGF-BP-3 in the patient’s blood before Acclydine was taken...

Value of IGF-BP-3 / IGF-1 General Response to Acclydine:

4.5 or greater : Greatest Probability of Response
3.5 to 4.5 : Some patients responded, some did not
Less than 3.5 : Most patients did not respond

The researchers concluded that Acclydine is best suited for patients with a ratio of IGF-BP-3/IGF-1 greater than 3.5. Patients with a ratio greater than 3.5 have a IGF-1 deficiency.

In the case the ratio is less than 3.5, but the concentration of IGF-1 is higher than normal, it might be useful to begin with a low dose of Acclydine, 1-2 capsules per day.

Methods: 90 individuals suffering from CFS (Holmes and/or Fukuda criteria) entered the study. They were not allowed to take any other medication than minor pain relievers and homeopathic medication.

The treatment protocol consisted of first 4 weeks: 250 mg four times a day in combination with amino acids; second 4 weeks 250 mg Acclydine twice daily in combination with amino acids. The primary efficacy variable was the change from baseline in CFS as measured by the Clinician’s Global Impression Scale (CGI) after 4 and 8 weeks of treatment. Secondary endpoints were: IGF-1, IGF-BP3 values, LMW/HMW RNase L ratio, GHQ-30, POMS, SF-36 and SCL-90.

Conclusions:
Acclydine in combination with amino acids gives an improvement in CFS symptoms (54% in the active group compared to 16% in the placebo group). No major adverse events were noted. Acclydine appears to be a safe and adequate drug for CFS.

This study was sponsored by
Optipharma ,The Netherlands.

HOWEVER, I found this on
CFSFMExperimental-yahoogroup:

"...and hasn't Asensio & Company been charged and on several counts fined by the court with manipulating stock and bringing about the destruction of many companies?
I wouldn't trust them as a source of information, because they have a vested interest in making money off their accusations, and they've gained a reputation for unethical behavior..."

Andrographis is believed to have immune-stimulating, anti-inflammatory, fertility-decreasing, liver-protective, and bile secretion-stimulating actions. Though some older studies suggested andrographis was antibacterial, modern research has been unable to confirm this finding.

... supposedly most helpful for the URI's (upper respiratory tract infections) that hit CFS patients. Also, clot busting.

Details on Andrographis can be found at:

Altcancer.com/andcan.htm

A preliminary uncontrolled study using isolated andrographolide found that while it tended to decrease viral load and increase CD4 lymphocyte levels in people with HIV infection, at the amount used, the preparation led to side effects, including headache, fatigue, a bitter/metallic taste in the mouth, and elevated liver enzymes (which returned to normal after the medication was stopped). It is unknown whether the andrographolides used in this study directly killed HIV or had an immune-strengthening effect.

"...The species name somnifera means "sleep-bearing" in Latin, indicating it was considered a sedative, but it has been also used for sexual vitality and as an adaptogen.
Some herbalists refer to ashwagandha as Indian ginseng, since it is used in ayurvedic medicine in a way similar to that ginseng is used in traditional Chinese medicine..."
Ashwagandha (Wikipedia)

"...Ashwagandha root, is an important herb from the Ayurvedic or Indian system of medicine. Ashwagandha has been traditionally used for the treatment of debility, emaciation, impotence, and premature aging. This dietary supplement is used to enhance mental and physical performance, improve learning ability, and decrease stress and fatigue.
Ashwagandha is a general tonic to be used in stressful situations, especially insomnia, overwork, nervousness, restlessness, and CFS..."
Immunesupport.com/articles

Boone K. Withania 1998
The Indian Ginseng and Anti-aging Adaptogen. Nutrition and Healing.

Singh A, Naidu PS, Gupta S, Kulkarni. 2002 Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food.

Chinese: Huang qi

Zhao KS, et al. 1990
Positive Modulating Action of Shengmaisan with Astragalus membranaceus on Anti-tumor Activity of LAK Cells.

"...One doctor gave me azithromycin for a sinus infection.
It did not help my sinus problems at all, but suddenly my stomach problems were much better.

I have since learned that azithromycin is one of the antibiotics used to treat mycoplasmas.
I had not yet heard of mycoplasmas, but it is now apparent that I may have had an infection..."
Cfs-recovery.org/mycoplasma

"The temporary initial benefits come crumbling down after not so long, probably because antibiotics don't address more key upstream issues in ME/CFS."
CFSFMExperimental-yahoogroup/message

Azithromycin Therapy May Be Beneficial for Subset of CFS Patients

In a group of 99 Chronic Fatigue Syndrome patients treated experimentally for six weeks with azithromycin, a subgroup of 58 patients reported a positive decrease in overall symptom severity. Azithromycin is an antibiotic, but is also believed to possess beneficial immunomodulation (immune system affecting) abilities.

...After the azithromycin treatment, the responders’ blood plasma levels of acetylcarnitine were lower on average than for the nonresponders.
The researchers speculate that the reason for the lower acetylcarnitine levels in the responders’ blood has to do with cellular energy production. Acetylcarnitine is involved in the cells’ normal use of fatty acids to produce energy (oxidation). They cite studies offering preliminary evidence of a relationship between CFS patients’ fatigue and dysfunction of cellular energy production, indicating “a complex response involving acetylcarnitine.”
Are the responders’ cells using more acetylcarnitine, for example?
Immunesupport.com/azithromycin

Recommendation by Dr. Jacob Teitelbaum:
Baclofen: 10 to 20mg 1 to 3 times a day (sedating).
Immunesupport.com/Dr. Jacob Teitelbaum
(Treatment Protocol for Chronic Fatigue Syndrome & Fibromyalgia)

Dr. Jay Goldstein's treatment protocol from the book "Betrayal by the Brain":
Ncf-net.org/forum/jay.htm

Carnitine
(L-Carnitine)
(Acetyl-L-carnitine)

Like all other proteinogenic amino acids natural carnitine is the L-stereoisomer. It can be synthesised within the body from the amino acids lysine or methionine.
Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. It has been speculated that during growth or pregnancy the requirement of carnitine could exceed its natural production.
Carnitine (Wikipedia)

Acetyl-L-carnitine or ALCAR, is an acetylated form of L-carnitine. ALCAR is far superior to normal L-carnitine in terms of bioavailability in that it is absorbed by the gastrointestinal tract, enters cells and crosses the blood-brain barrier more readily than unacetylated carnitine.

ALCAR has a broad range of uses including combination with alpha lipoic acid to comprise a patented formulation that has been evidenced to "rejuvenate" the mitochondria of aging mice in studies conducted by Bruce Ames and others. Accordingly, acetyl-L-carnitine has potential as a life extension supplement probably capable of improving the quality and possibily also extending the average life-span of humans. Other attributed uses for ALCAR include using it as a treatment for depression (250 mg per day for several weeks) and for clearing plaque/fatty deposits out of the veins and arteries.

Chlorella is more than 50% protein, 1.6% chlorophyll, and rich in carotenoids, RNA-DNA, B12 and magnesium.

Very similar in nutrients to spirulina & blue-green algae.
Beyondacenturyonline.com

Some were given the remedy and some a placebo over a 12-week period.

Researchers measured exercise capacity, endurance performance and metabolic alterations before, during and after receiving the remedy or placebo.

Oxygen

Volume of oxygen consumption went up 5.5% in the group given the remedy, but only 2.2% in the others, suggesting an increase in aerobic capacity.

The time taken to complete a one-mile walk was reduced by 29 seconds in the CordyMax group but increased slightly in the others. And diastolic blood pressure fell by 3.2% among people taking the remedy.

The researchers said: "This study provides scientific evidence that CordyMax is effective in enhancing aerobic exercise capability, endurance exercise performance, and exercise metabolism and alleviating fatigue in healthy humans."
Bbc.co.uk

Diazepam is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of minimum medical needs for a basic health care system. Diazepam is used to treat a wide range of conditions and is one of the most frequently prescribed benzodiazepines.

Treatment with DHEA or Melatonin alone, as well as together , prevented the reduction of B- and T-cell proliferation as well as of Th1 cytokine
secretion caused by retrovirus infection. Supplementation also suppressed the elevated production of Th2 cytokines stimulated by retrovirus infection.
(Zhang, Araghi-Niknam et al. 1999)

One study showed the value of DHEA and vitamin C infusion treatment in the control of cfs.
Refer to the
DHEA Replacement Therapy protocol before embarking on this therapy.

DHEA replacement therapy has become popular as an antiaging regimen and offers aging patients help in preventing diseases such as osteoporosis, fatigue, depression, atherosclerosis, and cancer.

DHEA (50 or 100 mg a day) was also shown to significantly elevate insulin growth factor (IGF). Aging causes a decline in IGF levels that contributes to the loss of lean body mass, as well as to excess fat accumulation, neurological impairment, and age-associated immune dysfunction.

One study showed the value of DHEA and
Vitamin C infusion treatment in the control of cfs.
(Kodama, Kodama et al. 1996)

A study of 15 subjects with CFS, 15 subjects with major depression, and 11 healthy subjects found that DHEA and DHEA-S levels were significantly lower in the cfs compared to the healthy group. DHEA-S levels, but not DHEA, were lower in the depressives. The authors concluded that DHEA has a potential role both therapeutically and as a
diagnostic tool, in CFS.
(Scott, Salahuddin et al. 1999)

Another study of DHEA levels in 22 CFS patients and 14 healthy controls found normal basal DHEA levels, but a blunted serum DHEA response curve to ACTH (adreno-corticotropic hormone) injection.
ACTH normally stimulates the adrenal
glands to secrete DHEA. The authors concluded that endocrine abnormalities play a role in CFS and that a relative glucocorticoid deficiency might contribute to the overall clinical picture in CFS. (De Becker, De Meirleir et al. 1999)

Use DHEA up to 4 months for full effect (?)

Remedyfind.com on DHEA

Essential fatty acid

Omega 3: Alpha-linolenic acid

Omega 6: Linoleic acid

Omega 9: Oil acid
(not essential ?)

Udo's choice oil blend offers Omega-3, 6, 9-acids in a 2:1:1 relation.

Inventor: Udo Erasmus
His book: "Fats that heal, fats that kill"

Distributor USA: Florahealth.com
Distributor Switzerland: Chrisana.ch

Udo's choice oil blend contains:
• Flax oil
• Sunflower oil
• Sesame oil
• Medium chain triglycerides
• Evening primrose oil (12.6 mg GLA per tablespoon)
• Rice germ & Bran oil
• Soy lecithin
• D-alpha tocopheral (natural Vitamin E)
• Oat germ & Bran oil.

One tablespoon liquid form contains:
• Calories 135
• Total fat 14.5 g
• Saturated fat 1.5 g
• Polyunsaturated fat: (Omega-3 fatty acids 6.4 g, Omega-6 fatty acids 3.2 g)
• Monounsaturated fat (Omega-9 fatty acids 3 g)
• Medium chain triglycerides 231 mg.

Udo's Choice® Ultimate Oil Blend does not contain preformed EPA and DHA as it is an all vegetarian product. EPA and DHA can only be obtained preformed in the form of fish oil. As we completely want to avoid the potential problems of contamination with persistent organic pollutants, such as dioxins, furans and PCBs, we only use seed oils in Udo's Choice® Ultimate Oil Blend. The particular combination we used provides the following "important" fatty acids:

1. Alpha-linolenic acid (ALA), 18:C3-n3, which is the parent of the omega-3 fatty acid series. If provided in sufficient amounts, ALA is converted into EPA and DHA. Furthermore, ALA has a host of beneficial biological effects on its own that are independent of conversion into EPA and DHA. To facilitate optimal conversion, it is necessary to provide all the cofactors used by the enzymes involved in the desaturation and elongation of essential fatty acids (EFAs). The main ones are zinc, magnesium, vitamin B3 (as niacin), vitamin B5, vitamin B6, selenium and vitamin E (preferably as natural mixed tocopherols). Also, the diet should contain sufficient amounts of protein (at least 20%E), have a low-glycemic index, have a high ratio of EFAs to saturated fats and an overall ratio of omega-6:omega-3 of no more than 4:1.

2. Linoleic acid (LA), 18:C2-n6, which is the parent of the omega-6 fatty acid series that includes gamma-linolenic acid (GLA), di-homo-gamma-linolenic acid (DGLA) and arachidonic acid (AA). If enough LA is provided, then the body can convert it into GLA and DGLA. The same issues as those for ALA also pertain to LA in terms of optimal conversion.

3. GLA, 18:C3-n6, in small amounts.

4. Lauric acid, 12:C0, which is known to stimulate the immune system and suspected of having an effect on certain groups of vira because it disrupts their lipid envelope.

If people get the recommended dosage of the oil blend, approx. one 15-ml tablespoon per 25 kg bodyweight daily and make sure they create the right environment in their body to facilitate optimal conversion (as mentioned above), then ample amounts of EPA, DHA and GLA should be produced in the body.

Feverfew
Tanacetum parthenium

Dr. Goldstein recommendation
---------------------------------------------
Dr. Jay Seastrunk:
Parke-Davis, the company that purchased gabapentin, has seen dosages that range from 3,000 to 6,000 mg per day while, even at 10,000, the drug is not toxic.
Dr. Seastrunk has never found anyone to be allergic to Neurontin in the hundreds of patients he has treated.
It does not cross-react with other medications. Magnesium, however, will block Neurontin.
Ncf-net.org (The National Forum)
Brain injury in cfids and mcs
Researchers explore many uses for Neurontin (Cfids.org)
---------------------------------------------
Dr. Paul Cheney:
...believes Neurontin can help "protect the brain" from further damage He has said that an injured brain may respond to lesser stimuli than a healthy brain, and this overstimulation of the brain may contribute to feelings of fatigue and pain. He has found that Neurontin seems to raise the sensitivity threshold of the brain’s pain response in CFIDS patients.
...Neuroprotection - The brain is injured in a monotonous way. It fires at lower threshold levels. Therefore, information density will confuse, sensitivity to light, pain intensified, cannot sleep, hearing is amplified. Drugs which treat this are magnesium, klonopin, neurontin, doxapin, nicotine, and narcotics. These need to be titrated at small optimum doses different for each patient. These drug perserve the brain from damage.
Lecture by Dr. Cheney, May 7, 1998
--------------------------------------------
Gabapentin (Wikipedia)

Components; Nutrients:

Calcium
Folate
Iron
Magnesium
Manganese
Phosphorus
Potassium
Selenium
Zinc
Vitamin B1 (Thiamine)
Vitamin B2 (Riboflavin)
Vitamin B3 (Niacin)
Vitamin C

- Increases brain oxygenation, transmission rate to nerve cells
- concentration, mental alertnes & memory
- circulation

Ginkgo supposedly also inhibits cortisol biosynthesis

Ginkgo Biloba and Nimodipine are probably the two most important treatments for normalising brain circulation in cfs/me.
It works by countering the viscosity produced by excess production of platelet activating factor (which thickens the blood).
Dr. David Mason Brown

Glutathione is one of the body's most important and powerful antioxidants. Glutathione also attaches to toxic molecules, which are then eliminated from the body (detoxification).

An article published in the journal Medical Hypothesis proposed
that glutathione, an antioxidant essential for lymphocyte function, may be depleted in cfs-patients.
Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also
causes the muscular fatigue and myalgia associated with cfs.
(Bounous and Molson 1999)

Cysteine is a precursor to glutathione. It has been hypothesized that glutathione and cysteine metabolism may play a role in skeletal muscle wasting and muscle fatigue. The combination of
abnormally low plasma cysteine and glutamine levels, low natural killer (NK) cell activity (with a resulting usceptibility to viral infection), skeletal muscle wasting or muscle fatigue,
and increased rates of urea production defines a complex of abnormalities that is tentatively called "low CG syndrome."
These symptoms are found in patients with HIV infection, cancer, major injuries, sepsis, Crohn's disease, ulcerative colitis, cfs, and to some extent in over-trained athletes.
(Droge and Holm 1997)

N-acetyl-cysteine is a precursor of glutathione that has been shown to be helpful against viruses (most of the research has been with HIV and Hepatitis infections).
(Sprietsma 1999)
(Weiss, Hildt et al. 1996)

- 1 cup spring water
- 1 cup seltzer water
- 1/4 tsp sea salt
- 1/4 tsp "no salt" brand salt substitute (potassium)
- Stevia sugar substitute is allowed, sugar is not. Flavoring is allowed

Drink 3 - 4 glasses daily. Observe blood pressure response. Consider stopping if blood pressure rises above 140/90.

Grapefruit seed extract is a strong antimicrobial with proven activity against bacteria and fungi. It also has antioxidant properties.
Grapefruit (Wikipedia)

- Polyphenol antioxidants
(A class of phytochemicals found in high concentrations in green tea, and have been associated with heart disease and cancer prevention. The slight astringent, bitter taste of green tea is attributed to polyphenols.
Dried leaves contain about 10% polyphenols.)

- Catechins
(A category of polyphenols.
In green tea, catechins are present in significant quantities, more specifically:
- epicatechin (EC),
- epigallocatechin (EGC),
- epicatechin gallate (ECG)
- epigallocatechin gallate (EGCG). EGCG makes up about 10-50% of the total catechin content and appears to be the most powerful of the catechins – with antioxidant activity about 25-100 times more potent than vitamins C and E.

- Theanine (amino acid that reportedly stimulates production of alpha waves)

contains also:

Tannins - A group of simple and complex phenol, polyphenol, and flavonoid compounds, bound with starches, and often so amorphous that they are classified as tannins simply because at some point in degradation they are astringent and contain variations on gallic acid. Produced by plants, tannins are generally protective substances found in the outer and inner tissues.
All of the tannins are relatively resistant to digestion or fermentation, and either decrease the ability of animals to easily consume the living plant, or, as in deciduous trees, cause shed parts of the plant to decay so slowly that there is little likelihood of infection to the living tree from rotting dead material around its base.
All tannins act as astringents, shrinking tissues and contracting structural proteins in the skin and mucosa.

(For a mouth rinse you can swallow, use Xylitol and Green Tea!)(?)

Health benefits of tea (Wikipedia)

1001herbs.com/hoshouwu

Hydrocortisone
(Cortisol)

...I think you're right about the FIR sauna promoting detox. Since PWCs tend to have lots of toxins stored up as a result of
glutathione depletion over extended times, this is probably a big factor in the FIR's benefits for PWCs.

I suspect that the FIR sauna simultaneously does several things that are beneficial to PWCs. As you probably know,
Jim Clements emphasizes the increase in body temperature and the resulting
increase in metabolic rate.

Sherry Rogers emphasizes the detox aspect.
I have hypothesized that it enables the sympathetic nervous system to:
Stop generating so much norepinephrine in the skin, to shut down the blood flow there, thus lifting the demand on glutathione to dispose of the oxidation product of norepinephrine, and also freeing up supplies of tyrosine and phenylalanine so that the sympathetic nervous system can make norepinephrine, to control pooling of blood in the legs, and to stop the orthostatic intolerance.

In view of all this, I suspect that the FIR sauna will have the biggest benefits for PWCs who have:
- a big toxin load,
- a lower than normal armpit temperature,
- orthostatic intolerance, and
- glutathione depletion.

Rich Van Konynenburg
CFSFMExperimental (at) yahoogroups

Hyperthermia in the form of hot baths has also proved useful in the treatment of herpes simplex and herpes zoster (shingles).

At first the treatment aggravates the situation, but conditions improve considerably after a short time.
It is also useful in treating the common cold and flu, as well as chronic fatigue syndrome.

The body protects itself from viruses, bacteria, and other harmful substances through the use of numerous defense systems.

One of these is fever. Fever raises the body's temperature above normal in an attempt to destroy invading organisms and sweat impurities out of the system.

Fever is a highly effective and natural process of curing disease and restoring health, and has been recognized as such for thousands of years. Hyperthermia deliberately creates fever in the patient in order to utilize this natural healing process.
Bodytrends.com

What is far infrared?
by Jim Clements

"Infrared Thermal System For Whole-Body Regenerative Radiant Therapy"
by Dr. Aaron M. Flickstein

"Warming Up to Far Infrared"
by D.J. Fletcher

"Detox in the Sauna"
by Lawrence Wilson, MD

"Turn Up the Heat; Improve Health with the Infra-red Sauna"
by Stefan Kuprowsky, MA, ND

"The Manual of Sauna Therapy"
by Dr. Lawrence D. Wilson MD

"Infrared Sauna"
by Dr. Jim Chan ND

"Energy Returns with Cellular Purification"

"250-Watt Infrared Heat Lamp Warnings"

Infraredsauna.net
(Medical info)

...when used orally for treating obsessive-compulsive disorder (OCD). In one small-scale, placebo-controlled trial, OCD patients receiving inositol for 6 weeks had significant improvement, based on Yale-Brown Obsessive Compulsive Scale scores, compared to placebo (2186).
Abstracts from:
Naturaldatabase.com


1'200 mg per day of myo-inositol has been effective (within 2 weeks) for some cfs-patients with hormonal problems.

Fights blurry vision (?)

Inositol (Wikipedia)

Anti-aging-drugs.com

Clonazepam (marketed by Roche under the trade-name Klonopin® in the United States and Rivotril® in Canada and Europe) is an anticonvulsant sedative-hypnotic anxiolytic (anti-anxiety drug), and a member of the benzodiazepine class of drugs.
Like other benzodiazepines, Clonazepam is believed to act by simulating the action of GABA on the central nervous system. Because of strong anxiolytic properties and euphoriant side-effects it is said to be among the class of 'high potent' benzodiazepines with a higher risk of abuse, misuse and dependence than other benzodiazepines.
The sedative effects of Clonazepam are relatively weak, compared to its strong anxiolytic and anticonvulsant effectivity.
250 micrograms (0.25mg) are equivalent to 5mg Diazepam.
Klonopin (Wikipedia)

Dr. Paul Cheney Discusses the Benefits of Klonopin
by Carol Sieverling
ImmuneSupport.com

10-12-2001

Editor’s Note: The following is based on a recent interview conducted by Carol Sieverling with Dr. Paul R. Cheney, M.D., Ph.D., and the article "CFIDS Treatment: The Cheney Clinic’s Strategic Approach" (CFIDS Chronicle, Spring 1995). Dr. Cheney gave permission to share this information, but has not reviewed or edited it.

Many CFIDS specialists prescribe the drug Klonopin. In the October 1999 issue of The Fibromyalgia Network, nine CFS/FM specialists summarized their most effective treatments, and six included Klonopin. Interestingly, the three who did not are primarily FM specialists.

Dr. Cheney prescribes Klonopin to address a condition associated with CFIDS called "excitatory neurotoxicity." To explain this condition to patients, he draws a line with "seizure" on the far left and "coma" on the far right. A big dot in the middle represents where healthy people are when awake. A dot somewhat to the right of the middle indicates where healthy people are when asleep – slightly shifted toward coma. He highlights in red the left portion of the line, from seizure to the middle, and labels it "Neurotoxic State" (damaging to the brain). He highlights in blue the right portion of the line, from coma to the middle, and labels it "Healing State."

In CFIDS, an ongoing injury to the brain shifts patients toward seizure. A dot to the left of the middle, marked "injury," represents the position of CFIDS patients. This puts us in the red "Neurotoxic" zone. When we shift toward seizure, we often experience "sensory overload." It’s as if our brain’s "radar" is too sensitive. Our neurons (nerve cells) are sensing stimuli and firing when they should not. This causes amplification of sensory input. Light, noise, motion and pain are all magnified. At the beginning of their illness, many patients report feeling exhausted, yet also strangely "wired." The "wired" feeling is the slight shift towards seizure that occurs as a result of the excitatory neurotoxicity.

Cheney frequently uses the term "threshold potential" when discussing excitatory neurotoxicity. (Think of the threshold - bottom - of a doorway. The lower it is, the more accessible it is. When it is at floor level, everything can enter. When it is raised, access is restricted to taller people. If it is too high, no one can enter.) Threshold potential refers to how much stimulus it takes to make neurons fire. If the threshold potential is too low, even slight stimulation is "allowed to enter" and is detected by the neurons. This causes the neurons to fire, resulting in sensory overload. If the threshold is dropped to nothing, all stimuli get through and the neurons fire continuously, resulting in a seizure. If the threshold is raised, only stronger stimuli can make neurons fire. A healthy person’s threshold potential naturally rises at bedtime, promoting sleep. If the threshold potential is too high, you feel drugged or drowsy. If the threshold potential is raised extremely high, coma results.

In CFIDS, NMDA is more activated than GABA, lowering the threshold potential. This causes neurons to fire with very little stimulation, resulting in sensory overload. This condition of excitatory neurotoxicity is dangerous. Dr. Cheney emphasizes that in an attempt to protect itself, the body will eventually kill neurons that fire excessively. He states that brain cell loss can result if this condition isn’t addressed.

How can the brain be protected against excitatory neurotoxicity? Klonopin. This long acting benzodiazepine has been Dr. Cheney’s most effective drug for CFIDS over the years. He believes that Klonopin and the supplement magnesium may be two of the most important treatments for CFIDS patients because of t